When it comes to cannabis policy, Missouri has been one of the most restrictive states. Just like it was the case with other states, Missouri prohibited all forms of cannabis in the early 1900s and had harsh penalties for those selling and possessing it. But at the end of the century, governments began to respond to pressure from physicians and patients by introducing the first laws to make cannabis available for medical use. Missouri became the 35th state to do so by introducing the legislation in 1994. However, marijuana still wasn’t recognized as medicine under federal law, so it was difficult to enforce the new legislation.